(transitive) to separate, to detach (to disunite from a group or mass; to disconnect)
(transitive) to break up, to split up (a couple or group that the subject of the sentence is not a part of)
Cariño, ¡despierta! Tu madre siempre ha estado tratando de separarnos.Babe, wake up! Your mother has always been trying to break us up.
(reflexive) to break up, to split up, to separate (e.g. a relationship, a band, a fight)
(takes a reflexive pronoun) to split off, to split up, to split apart, to separate
(takes a reflexive pronoun) to part, to detach
separarse de ― to detach from
(reflexive) to detach (oneself)
