to know (a fact)
Sé que volverá. ― I know it'll come back.
Lo siguiente que sé... ― Next thing I know...
to know how to do something
Sabe hablar español. ― He knows how to speak Spanish.
(in the preterite tense) to find out, to learn
to taste
Sabe a pollo. ― It tastes like chicken.
to realize, to know (e.g. recognize)
El hombre no sabe lo talentoso que su hijo es. ― The man doesn't realize how talented his son is.
to tell, to know (i.e. to discern or distinguish if something is the case)
Siempre es difícil saber si me mientes. ― It's always hard to tell if you're lying to me.
(informal) to figure out
Todavía estamos tratando de saber qué acaba de pasar. ― We're still trying to figure out what just happened.
to hear from (+ de)
No he sabido nada de ella en meses. ― I haven't heard from her in months.
to hear of, to hear about, (+ de)
to learn of, to learn about, to find out about, to know about (+ de)
(reflexive) to be known
Ya se sabe que uno de los factores que aceleran esta enfermedad es el estrés.It is known that one of the factors that speeds up this disease is stress.
(reflexive) to know (extremely well)
He oído que te sabes todas las líneas de la película de memoria.I heard you know all the lines of the movie by heart.